{"id":1237,"date":"2021-11-02T10:12:58","date_gmt":"2021-11-02T09:12:58","guid":{"rendered":"https:\/\/p2med.imibic.org\/?page_id=1237"},"modified":"2023-02-22T11:43:23","modified_gmt":"2023-02-22T10:43:23","slug":"fluvac-tregs","status":"publish","type":"page","link":"https:\/\/p2med.imibic.org\/?page_id=1237","title":{"rendered":"FluVac-Tregs"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1294 alignleft\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2021\/11\/Alexander-Batista-Duharte-e1635844308254-1024x1008.png\" alt=\"\" width=\"174\" height=\"171\" srcset=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2021\/11\/Alexander-Batista-Duharte-e1635844308254-1024x1008.png 1024w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2021\/11\/Alexander-Batista-Duharte-e1635844308254-300x295.png 300w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2021\/11\/Alexander-Batista-Duharte-e1635844308254-768x756.png 768w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2021\/11\/Alexander-Batista-Duharte-e1635844308254.png 1108w\" sizes=\"auto, (max-width: 174px) 100vw, 174px\" \/><strong>Alexander Batista Duharte <\/strong>(MD, PhD) belongs to the IMIBIC group GC01 Immunology and Allergy, led by Prof. Rafael Solana Lara. Alexander&#8217;s research project is titled <strong>FluVag-Tregs \u2013 Immunosenescence and immune responses to influenza vaccination. Use of antisense oligonucleotides targeting regulatory T cells to improve vaccine efficacy in old mice.<\/strong> The expected results of this project will increase the understanding of the biology in immunosenescence and allow to evaluate the relevance of its modulation to increase the anti-influenza-vaccine efficacy in old age. The project will last from October 2021 till September 2024.<\/p>\n\t\t\t\t\t\t<style>\r\n\t\t\t\t#wpsm_accordion_1244 .wpsm_panel-heading{\r\n\tpadding:0px !important;\r\n}\r\n#wpsm_accordion_1244 .wpsm_panel-title {\r\n\tmargin:0px !important; \r\n\ttext-transform:none !important;\r\n\tline-height: 1 !important;\r\n}\r\n#wpsm_accordion_1244 .wpsm_panel-title a{\r\n\ttext-decoration:none;\r\n\toverflow:hidden;\r\n\tdisplay:block;\r\n\tpadding:0px;\r\n\tfont-size: 16px !important;\r\n\tfont-family: Arial !important;\r\n\tcolor:#000000 !important;\r\n\tborder-bottom:0px !important;\r\n}\r\n\r\n#wpsm_accordion_1244 .wpsm_panel-title a:focus {\r\noutline: 0px !important;\r\n}\r\n\r\n#wpsm_accordion_1244 .wpsm_panel-title a:hover, #wpsm_accordion_1244 .wpsm_panel-title a:focus {\r\n\tcolor:#000000 !important;\r\n}\r\n#wpsm_accordion_1244 .acc-a{\r\n\tcolor: #000000 !important;\r\n\tbackground-color:#d0ffdd !important;\r\n\tborder-color: #ddd;\r\n}\r\n#wpsm_accordion_1244 .wpsm_panel-default > .wpsm_panel-heading{\r\n\tcolor: #000000 !important;\r\n\tbackground-color: #d0ffdd !important;\r\n\tborder-color: #d0ffdd !important;\r\n\tborder-top-left-radius: 0px;\r\n\tborder-top-right-radius: 0px;\r\n}\r\n#wpsm_accordion_1244 .wpsm_panel-default {\r\n\t\tborder:1px solid transparent !important;\r\n\t}\r\n#wpsm_accordion_1244 {\r\n\tmargin-bottom: 20px;\r\n\toverflow: hidden;\r\n\tfloat: none;\r\n\twidth: 100%;\r\n\tdisplay: block;\r\n}\r\n#wpsm_accordion_1244 .ac_title_class{\r\n\tdisplay: block;\r\n\tpadding-top: 12px;\r\n\tpadding-bottom: 12px;\r\n\tpadding-left: 15px;\r\n\tpadding-right: 15px;\r\n}\r\n#wpsm_accordion_1244  .wpsm_panel {\r\n\toverflow:hidden;\r\n\t-webkit-box-shadow: 0 0px 0px rgba(0, 0, 0, .05);\r\n\tbox-shadow: 0 0px 0px rgba(0, 0, 0, .05);\r\n\t\tborder-radius: 4px;\r\n\t}\r\n#wpsm_accordion_1244  .wpsm_panel + .wpsm_panel {\r\n\t\tmargin-top: 5px;\r\n\t}\r\n#wpsm_accordion_1244  .wpsm_panel-body{\r\n\tbackground-color:#f8f8f8 !important;\r\n\tcolor:#000000 !important;\r\n\tborder-top-color: #d0ffdd !important;\r\n\tfont-size:14px !important;\r\n\tfont-family: Arial !important;\r\n\toverflow: hidden;\r\n\t\tborder: 2px solid transparent !important;\r\n\t}\r\n\r\n#wpsm_accordion_1244 .ac_open_cl_icon{\r\n\tbackground-color:#d0ffdd !important;\r\n\tcolor: #000000 !important;\r\n\tfloat:right !important;\r\n\tpadding-top: 12px !important;\r\n\tpadding-bottom: 12px !important;\r\n\tline-height: 1.0 !important;\r\n\tpadding-left: 15px !important;\r\n\tpadding-right: 15px !important;\r\n\tdisplay: inline-block !important;\r\n}\r\n\r\n\t\t\t\r\n\t\t\t\t\r\n\t\r\n\t\t\t<\/style>\r\n\t\t\t<div class=\"wpsm_panel-group\" id=\"wpsm_accordion_1244\" >\r\n\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t<!-- Inner panel Start -->\r\n\t\t\t\t\t<div class=\"wpsm_panel wpsm_panel-default\">\r\n\t\t\t\t\t\t<div class=\"wpsm_panel-heading\" role=\"tab\" >\r\n\t\t\t\t\t\t  <h4 class=\"wpsm_panel-title\">\r\n\t\t\t\t\t\t\t<a  class=\"\"  data-toggle=\"collapse\" data-parent=\"\" href=\"javascript:void(0)\" data-target=\"#ac_1244_collapse1\"  >\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"ac_open_cl_icon fa fa-plus\"><\/span>\r\n\t\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\t \r\n\t\t\t\t\t\t\t\t<span class=\"ac_title_class\">\r\n\t\t\t\t\t\t\t\t\tAbstract\t\t\t\t\t\t\t\t<\/span>\r\n\t\t\t\t\t\t\t<\/a>\r\n\t\t\t\t\t\t  <\/h4>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t<div id=\"ac_1244_collapse1\" class=\"wpsm_panel-collapse collapse \"  >\r\n\t\t\t\t\t\t  <div class=\"wpsm_panel-body\">\r\n\t\t\t\t\t\t\t<p> Influenza has a major impact on the elderly due to the increased susceptibility to infection and poor response to available vaccines. Several studies suggest that enhanced frequency of regular T cells (Tregs) in old age can be involved in the poor responses induces post-influenza vaccination. Therefore it has been suggested that one way to increase the efficacy of influenza vaccines might be to reduce the immunosuppressive effect of these cells. However, the functional effort of Tregs on the immune response to the influenza vaccine and hot its modulation can improve the response to vaccination in the old age has not been sufficiently studied. <\/p>\r\n\r\n<p>The present project aims to evaluate comparatively the role of Tregs in the immunogenicity of influenza vaccine in mice in two steps of life: young and old mice. In the first phase,  mice model using an anti-Fop3 antisence oligonucleotide (ASO) for depleting Tregs will be used to measure the effect of these cells on clonal immune response mediated by T-helper, CD8+T, NK and B cells. Thus, the effect of immunosenescence on Tregs response to vaccination and their effects in the vaccine immunogenicity will be assessed.<\/p>\r\n\r\n<p>In the second phase of the project, the effect of three ASOs (anti-Foxp3, anti PD1\/PDL1, and anti-CTLA-A) will be evaluated as vaccine adjuvants to improve the influenza vaccine immunogenicity and protective efficacy in elderly.<\/p>\r\n\r\n<p>The result of this project will allow progress in comprehension of the Tregs biology in immunosenescence and to evaluate the relevance of this modulation to increase the anti-influenza-vaccine efficacy in old age. In addition, this project will allow me to reach the highest level of independence and development as a researcher. Here I will apply and improve the skills learned so far and I will acquire knowledge of new tools for preclinical studies of vaccines of great impact and with potential clinical application. <\/p>\r\n\r\n\t\t\t\t\t\t  <\/div>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<!-- Inner panel End -->\r\n\t\t\t\t\t\r\n\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t<!-- Inner panel Start -->\r\n\t\t\t\t\t<div class=\"wpsm_panel wpsm_panel-default\">\r\n\t\t\t\t\t\t<div class=\"wpsm_panel-heading\" role=\"tab\" >\r\n\t\t\t\t\t\t  <h4 class=\"wpsm_panel-title\">\r\n\t\t\t\t\t\t\t<a  class=\"collapsed\"  data-toggle=\"collapse\" data-parent=\"\" href=\"javascript:void(0)\" data-target=\"#ac_1244_collapse2\"  >\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"ac_open_cl_icon fa fa-plus\"><\/span>\r\n\t\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\t \r\n\t\t\t\t\t\t\t\t<span class=\"ac_title_class\">\r\n\t\t\t\t\t\t\t\t\tObjectives\t\t\t\t\t\t\t\t<\/span>\r\n\t\t\t\t\t\t\t<\/a>\r\n\t\t\t\t\t\t  <\/h4>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t<div id=\"ac_1244_collapse2\" class=\"wpsm_panel-collapse collapse \"  >\r\n\t\t\t\t\t\t  <div class=\"wpsm_panel-body\">\r\n\t\t\t\t\t\t\t<p>The main objectives of FluVac-Tregs are to:<\/p>\r\n\r\n<p><strong>Objective 1<\/strong>: To evaluate the role of Tregs in the immune response to influenza vaccine in two steps of life: Young and old ages in mice.<\/p>\r\n\r\n<p><strong>Objective 2<\/strong>: To evaluate the effect of three ASOs (ASOs (anti-Foxp3, anti PD1\/PDL1, and anti-CTLA-A) as adjuvant to improve the immune response induced by influenza vaccine in old mice and their safety profile.<\/p>\r\n\r\n<p><strong>Objective 3<\/strong>: To evaluate the effect of the selected ASOs in the improvement of the protective anti-influenza immune response after a viral challenge in old mice.<\/p>\r\n\t\t\t\t\t\t  <\/div>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<!-- Inner panel End -->\r\n\t\t\t\t\t\r\n\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\n<h4>Dissemination Activities<\/h4>\n<p>&nbsp;<\/p>\n<p><em><strong>New Research Article<\/strong><\/em><\/p>\n<p><a href=\"https:\/\/www.mdpi.com\/1422-0067\/24\/3\/2194\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-1672\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2023\/02\/ijms-24-02194-v2-e1676468494470.png\" alt=\"\" width=\"518\" height=\"720\" srcset=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2023\/02\/ijms-24-02194-v2-e1676468494470.png 518w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2023\/02\/ijms-24-02194-v2-e1676468494470-216x300.png 216w\" sizes=\"auto, (max-width: 518px) 100vw, 518px\" \/><\/a><\/p>\n<p class=\"title hypothesis_container\">A Straightforward Cytometry-Based Protocol for the Comprehensive Analysis of the Inflammatory Valve Infiltrate in Aortic Stenosis. Jan 2023<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-498\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta.png\" alt=\"\" width=\"940\" height=\"5\" srcset=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta.png 940w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta-300x2.png 300w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta-768x4.png 768w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta-670x5.png 670w\" sizes=\"auto, (max-width: 940px) 100vw, 940px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1669 alignleft\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2023\/02\/Ditico-Alexander-Batista.jpg\" alt=\"\" width=\"250\" height=\"141\" srcset=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2023\/02\/Ditico-Alexander-Batista.jpg 1280w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2023\/02\/Ditico-Alexander-Batista-300x169.jpg 300w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2023\/02\/Ditico-Alexander-Batista-1024x576.jpg 1024w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2023\/02\/Ditico-Alexander-Batista-768x432.jpg 768w\" sizes=\"auto, (max-width: 250px) 100vw, 250px\" \/><strong>Science Talk Series<\/strong> at the Faculty of Sciences, University of Cordoba. On 13 December 2022, Alexander talked about &#8220;Ageing and Immunity: Strategies for Vaccine Development&#8221;.<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-1670\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2023\/02\/Seminario1-3-e1676467846900.jpeg\" alt=\"\" width=\"466\" height=\"280\" srcset=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2023\/02\/Seminario1-3-e1676467846900.jpeg 1200w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2023\/02\/Seminario1-3-e1676467846900-300x180.jpeg 300w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2023\/02\/Seminario1-3-e1676467846900-1024x614.jpeg 1024w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2023\/02\/Seminario1-3-e1676467846900-768x461.jpeg 768w\" sizes=\"auto, (max-width: 466px) 100vw, 466px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-498\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta.png\" alt=\"\" width=\"940\" height=\"5\" srcset=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta.png 940w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta-300x2.png 300w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta-768x4.png 768w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta-670x5.png 670w\" sizes=\"auto, (max-width: 940px) 100vw, 940px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1606 alignleft\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/09\/IMG-20220926-WA0001-300x288.jpg\" alt=\"\" width=\"225\" height=\"216\" srcset=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/09\/IMG-20220926-WA0001-300x288.jpg 300w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/09\/IMG-20220926-WA0001-1024x984.jpg 1024w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/09\/IMG-20220926-WA0001-768x738.jpg 768w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/09\/IMG-20220926-WA0001.jpg 1080w\" sizes=\"auto, (max-width: 225px) 100vw, 225px\" \/><\/p>\n<p><strong>XL Congress of the Spanish Society of Physiological Sciences. Joint meeting between Spanish and Portuguese physiologists<\/strong>. At the meeting in Badajoz, on 20<sup>th<\/sup> September 2022, Alexander presented \u201cRegulatory T cells, immunosenescence and cancer. Prospects for vaccine development\u201d.<\/p>\n<p><span style=\"font-size: 14px;\">\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1607 aligncenter\" style=\"font-family: Helvetica, sans-serif;\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/09\/IMG-20220926-WA0000-300x169.jpg\" alt=\"\" width=\"478\" height=\"269\" srcset=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/09\/IMG-20220926-WA0000-300x169.jpg 300w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/09\/IMG-20220926-WA0000-1024x576.jpg 1024w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/09\/IMG-20220926-WA0000-768x432.jpg 768w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/09\/IMG-20220926-WA0000-1536x864.jpg 1536w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/09\/IMG-20220926-WA0000.jpg 2016w\" sizes=\"auto, (max-width: 478px) 100vw, 478px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-498\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta.png\" alt=\"\" width=\"940\" height=\"5\" srcset=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta.png 940w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta-300x2.png 300w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta-768x4.png 768w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta-670x5.png 670w\" sizes=\"auto, (max-width: 940px) 100vw, 940px\" \/><\/p>\n<p><em><strong>European Researchers&#8217; Night 2022<\/strong><\/em><\/p>\n<p><a href=\"https:\/\/lanochedelosinvestigadores.fundaciondescubre.es\/actividades\/cuando-la-edad-pasa-factura-por-que-te-haces-mayor\/\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1590 alignleft\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/09\/Patios-of-Science-2022-Alexander-BD.png\" alt=\"\" width=\"287\" height=\"285\" srcset=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/09\/Patios-of-Science-2022-Alexander-BD.png 609w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/09\/Patios-of-Science-2022-Alexander-BD-300x298.png 300w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/09\/Patios-of-Science-2022-Alexander-BD-150x150.png 150w\" sizes=\"auto, (max-width: 287px) 100vw, 287px\" \/><\/a>Why do we age?<\/p>\n<p>Join <a href=\"https:\/\/lanochedelosinvestigadores.fundaciondescubre.es\/investigador\/alexander-batista-duharte\/\" target=\"_blank\" rel=\"noopener\">Alexander<\/a> and other researchers and citizens on the 1st of October (20:30-20:00) to talk about ageing, what happens to our cells and immune system, what inflammation has to do with us getting old, what makes our skin wrinkle, and much more!<\/p>\n<p>More information about this event and reservations <a href=\"https:\/\/lanochedelosinvestigadores.fundaciondescubre.es\/actividades\/cuando-la-edad-pasa-factura-por-que-te-haces-mayor\/\" target=\"_blank\" rel=\"noopener\">here.<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1609 aligncenter\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/10\/Noche-europea-inv-Plaza-de-las-Tazas-dia-1-oct-2022-300x169.jpeg\" alt=\"\" width=\"487\" height=\"274\" srcset=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/10\/Noche-europea-inv-Plaza-de-las-Tazas-dia-1-oct-2022-300x169.jpeg 300w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/10\/Noche-europea-inv-Plaza-de-las-Tazas-dia-1-oct-2022-1024x576.jpeg 1024w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/10\/Noche-europea-inv-Plaza-de-las-Tazas-dia-1-oct-2022-768x432.jpeg 768w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/10\/Noche-europea-inv-Plaza-de-las-Tazas-dia-1-oct-2022-1536x864.jpeg 1536w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/10\/Noche-europea-inv-Plaza-de-las-Tazas-dia-1-oct-2022.jpeg 1600w\" sizes=\"auto, (max-width: 487px) 100vw, 487px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-498\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta.png\" alt=\"\" width=\"940\" height=\"5\" srcset=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta.png 940w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta-300x2.png 300w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta-768x4.png 768w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta-670x5.png 670w\" sizes=\"auto, (max-width: 940px) 100vw, 940px\" \/><span id=\"undefined\" class=\"markedContent\"><\/span><\/p>\n<p><em><strong>IMIBIC Research Seminar. O<\/strong><\/em>n the 8th of February 2022, Alexander presented his newly started project to other IMIBIC groups, UCO students, and staff of the hospital, under the title <span id=\"page3R_mcid0\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">&#8220;Regulatory T cells and vaccines. New approaches to <\/span><\/span><span id=\"page3R_mcid1\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">improve the effectiveness of immunization&#8221;.<\/span><\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-large wp-image-1582\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/08\/Alexander-Intergroup-Seminar-IMIBIC-2022-1024x396.jpg\" alt=\"\" width=\"700\" height=\"271\" srcset=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/08\/Alexander-Intergroup-Seminar-IMIBIC-2022-1024x396.jpg 1024w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/08\/Alexander-Intergroup-Seminar-IMIBIC-2022-300x116.jpg 300w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/08\/Alexander-Intergroup-Seminar-IMIBIC-2022-768x297.jpg 768w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/08\/Alexander-Intergroup-Seminar-IMIBIC-2022-1536x595.jpg 1536w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/08\/Alexander-Intergroup-Seminar-IMIBIC-2022-2048x793.jpg 2048w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-498\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta.png\" alt=\"\" width=\"940\" height=\"5\" srcset=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta.png 940w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta-300x2.png 300w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta-768x4.png 768w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta-670x5.png 670w\" sizes=\"auto, (max-width: 940px) 100vw, 940px\" \/><\/p>\n<p><span id=\"undefined\" class=\"markedContent\"><\/span><span id=\"undefined\" class=\"markedContent\"><\/span><span id=\"undefined\" class=\"markedContent\"><\/span><span id=\"undefined\" class=\"markedContent\"><\/span><span id=\"undefined\" class=\"markedContent\"><\/span><span id=\"undefined\" class=\"markedContent\"><\/span><span id=\"undefined\" class=\"markedContent\"><\/span><span id=\"undefined\" class=\"markedContent\"><\/span><span id=\"undefined\" class=\"markedContent\"><\/span><span id=\"undefined\" class=\"markedContent\"><\/span><span id=\"undefined\" class=\"markedContent\"><\/span><span id=\"page3R_mcid0\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\"><strong><em>Invited seminar<\/em><\/strong> at the Charles University in Prague, on April 19th 2022. The seminar was titled &#8220;Regulatory T cells and vaccines. New approaches to <\/span><\/span><span id=\"page3R_mcid1\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">improve the effectiveness of immunization&#8221;<\/span><\/span><\/p>\n<p><span id=\"page3R_mcid1\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1580 alignleft\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/08\/Charles-University-Prague_seminar-april-2022_b-1024x565.png\" alt=\"\" width=\"287\" height=\"158\" srcset=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/08\/Charles-University-Prague_seminar-april-2022_b-1024x565.png 1024w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/08\/Charles-University-Prague_seminar-april-2022_b-300x165.png 300w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/08\/Charles-University-Prague_seminar-april-2022_b-768x424.png 768w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/08\/Charles-University-Prague_seminar-april-2022_b-1536x847.png 1536w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/08\/Charles-University-Prague_seminar-april-2022_b.png 1539w\" sizes=\"auto, (max-width: 287px) 100vw, 287px\" \/><\/span><\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1579 alignnone\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/08\/Charles-University-Prague_seminar-april-2022-1024x579.png\" alt=\"\" width=\"277\" height=\"157\" srcset=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/08\/Charles-University-Prague_seminar-april-2022-1024x579.png 1024w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/08\/Charles-University-Prague_seminar-april-2022-300x170.png 300w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/08\/Charles-University-Prague_seminar-april-2022-768x434.png 768w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/08\/Charles-University-Prague_seminar-april-2022.png 1174w\" sizes=\"auto, (max-width: 277px) 100vw, 277px\" \/><\/p>\n<p>See <a href=\"https:\/\/drive.google.com\/file\/d\/1DleF-Fbw843I3ohtcYKmudtFhQhzM1BR\/view\" target=\"_blank\" rel=\"noopener\">the recording of the seminar.<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-498\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta.png\" alt=\"\" width=\"940\" height=\"5\" srcset=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta.png 940w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta-300x2.png 300w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta-768x4.png 768w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta-670x5.png 670w\" sizes=\"auto, (max-width: 940px) 100vw, 940px\" \/><\/p>\n<p><strong><em>Review Article<\/em><\/strong><\/p>\n<div id=\"attachment_1571\" style=\"width: 581px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.mdpi.com\/1999-4923\/14\/8\/1721\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-1571\" class=\"size-full wp-image-1571\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/08\/Pharmaceutics-Publication-2022.png\" alt=\"\" width=\"571\" height=\"819\" srcset=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/08\/Pharmaceutics-Publication-2022.png 571w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/08\/Pharmaceutics-Publication-2022-209x300.png 209w\" sizes=\"auto, (max-width: 571px) 100vw, 571px\" \/><\/a><p id=\"caption-attachment-1571\" class=\"wp-caption-text\">Immune Checkpoint Inhibitors for Vaccine Improvements: Current Status and New Approaches<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Alexander Batista Duharte (MD, PhD) belongs to the IMIBIC group GC01 Immunology and Allergy, led by Prof. Rafael Solana Lara. Alexander&#8217;s research project is titled FluVag-Tregs \u2013 Immunosenescence and immune responses to influenza vaccination. Use of antisense oligonucleotides targeting regulatory&hellip; <\/p>\n","protected":false},"author":2,"featured_media":1672,"parent":931,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-1237","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=\/wp\/v2\/pages\/1237","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1237"}],"version-history":[{"count":18,"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=\/wp\/v2\/pages\/1237\/revisions"}],"predecessor-version":[{"id":1679,"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=\/wp\/v2\/pages\/1237\/revisions\/1679"}],"up":[{"embeddable":true,"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=\/wp\/v2\/pages\/931"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=\/wp\/v2\/media\/1672"}],"wp:attachment":[{"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1237"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}