{"id":923,"date":"2021-02-11T17:39:01","date_gmt":"2021-02-11T16:39:01","guid":{"rendered":"https:\/\/p2med.imibic.org\/?page_id=923"},"modified":"2023-10-02T11:27:15","modified_gmt":"2023-10-02T09:27:15","slug":"gliochem","status":"publish","type":"page","link":"https:\/\/p2med.imibic.org\/?page_id=923","title":{"rendered":"GLIOCHEM"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1010 alignleft\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2021\/02\/Maribel-redoda-2.png\" alt=\"Maribel Mart\u00ednez Mac\u00edas\" width=\"159\" height=\"157\" \/><strong>Maribel Mart\u00ednez Mac\u00edas<\/strong> (PhD) is a member of the IMIBIC group GC22 Epigenetics, under the supervision of the group leader Prof. Teresa Rold\u00e1n. Her project is titled <strong>GLIOCHEM &#8211; Repair of temozolomide-induced DNA damage in tumour cells: role in glioblastoma resistance to chemotherapy<\/strong>. This project aims to generate new knowledge on the molecular mechanisms involved in resistance to temozolomide, a DNA methylating agent used in the treatment of several types of cancer including glioblastoma (brain tumour). Moving towards personalised cancer therapy, the expected results include the identification of new therapeutic targets and predictive biomarkers for methylating anticancer treatment. Maribel&#8217;s project will last from January 2021 till December 2023.<\/p>\n\t\t\t\t\t\t<style>\r\n\t\t\t\t#wpsm_accordion_1101 .wpsm_panel-heading{\r\n\tpadding:0px !important;\r\n}\r\n#wpsm_accordion_1101 .wpsm_panel-title {\r\n\tmargin:0px !important; \r\n\ttext-transform:none !important;\r\n\tline-height: 1 !important;\r\n}\r\n#wpsm_accordion_1101 .wpsm_panel-title a{\r\n\ttext-decoration:none;\r\n\toverflow:hidden;\r\n\tdisplay:block;\r\n\tpadding:0px;\r\n\tfont-size: 16px !important;\r\n\tfont-family: Arial !important;\r\n\tcolor:#000000 !important;\r\n\tborder-bottom:0px !important;\r\n}\r\n\r\n#wpsm_accordion_1101 .wpsm_panel-title a:focus {\r\noutline: 0px !important;\r\n}\r\n\r\n#wpsm_accordion_1101 .wpsm_panel-title a:hover, #wpsm_accordion_1101 .wpsm_panel-title a:focus {\r\n\tcolor:#000000 !important;\r\n}\r\n#wpsm_accordion_1101 .acc-a{\r\n\tcolor: #000000 !important;\r\n\tbackground-color:#c86d40 !important;\r\n\tborder-color: #ddd;\r\n}\r\n#wpsm_accordion_1101 .wpsm_panel-default > .wpsm_panel-heading{\r\n\tcolor: #000000 !important;\r\n\tbackground-color: #c86d40 !important;\r\n\tborder-color: #c86d40 !important;\r\n\tborder-top-left-radius: 0px;\r\n\tborder-top-right-radius: 0px;\r\n}\r\n#wpsm_accordion_1101 .wpsm_panel-default {\r\n\t\tborder:1px solid transparent !important;\r\n\t}\r\n#wpsm_accordion_1101 {\r\n\tmargin-bottom: 20px;\r\n\toverflow: hidden;\r\n\tfloat: none;\r\n\twidth: 100%;\r\n\tdisplay: block;\r\n}\r\n#wpsm_accordion_1101 .ac_title_class{\r\n\tdisplay: block;\r\n\tpadding-top: 12px;\r\n\tpadding-bottom: 12px;\r\n\tpadding-left: 15px;\r\n\tpadding-right: 15px;\r\n}\r\n#wpsm_accordion_1101  .wpsm_panel {\r\n\toverflow:hidden;\r\n\t-webkit-box-shadow: 0 0px 0px rgba(0, 0, 0, .05);\r\n\tbox-shadow: 0 0px 0px rgba(0, 0, 0, .05);\r\n\t\tborder-radius: 4px;\r\n\t}\r\n#wpsm_accordion_1101  .wpsm_panel + .wpsm_panel {\r\n\t\tmargin-top: 5px;\r\n\t}\r\n#wpsm_accordion_1101  .wpsm_panel-body{\r\n\tbackground-color:#f8f8f8 !important;\r\n\tcolor:#000000 !important;\r\n\tborder-top-color: #c86d40 !important;\r\n\tfont-size:14px !important;\r\n\tfont-family: Arial !important;\r\n\toverflow: hidden;\r\n\t\tborder: 2px solid transparent !important;\r\n\t}\r\n\r\n#wpsm_accordion_1101 .ac_open_cl_icon{\r\n\tbackground-color:#c86d40 !important;\r\n\tcolor: #000000 !important;\r\n\tfloat:right !important;\r\n\tpadding-top: 12px !important;\r\n\tpadding-bottom: 12px !important;\r\n\tline-height: 1.0 !important;\r\n\tpadding-left: 15px !important;\r\n\tpadding-right: 15px !important;\r\n\tdisplay: inline-block !important;\r\n}\r\n\r\n\t\t\t\r\n\t\t\t\t\r\n\t\r\n\t\t\t<\/style>\r\n\t\t\t<div class=\"wpsm_panel-group\" id=\"wpsm_accordion_1101\" >\r\n\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t<!-- Inner panel Start -->\r\n\t\t\t\t\t<div class=\"wpsm_panel wpsm_panel-default\">\r\n\t\t\t\t\t\t<div class=\"wpsm_panel-heading\" role=\"tab\" >\r\n\t\t\t\t\t\t  <h4 class=\"wpsm_panel-title\">\r\n\t\t\t\t\t\t\t<a  class=\"\"  data-toggle=\"collapse\" data-parent=\"\" href=\"javascript:void(0)\" data-target=\"#ac_1101_collapse1\"  >\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"ac_open_cl_icon fa fa-plus\"><\/span>\r\n\t\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\t \r\n\t\t\t\t\t\t\t\t<span class=\"ac_title_class\">\r\n\t\t\t\t\t\t\t\t\tAbstract\t\t\t\t\t\t\t\t<\/span>\r\n\t\t\t\t\t\t\t<\/a>\r\n\t\t\t\t\t\t  <\/h4>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t<div id=\"ac_1101_collapse1\" class=\"wpsm_panel-collapse collapse \"  >\r\n\t\t\t\t\t\t  <div class=\"wpsm_panel-body\">\r\n\t\t\t\t\t\t\tGlioblastoma (GBM) is an aggressive form of brain cancer with a low survival rate, due in large part to resistance to temozolomide (TMZ), a DNA methylating agent used in combination with radiotherapy as first-line treatment after surgery. The major lesion induced by TMZ is methylated guanine (N7-meG), which is frequently lost from DNA creating toxic abasic sites (AP sites). AP sites are repaired through a Base Excision Repair (BER) pathway initiated either by AP endonucleases or by AP lyases. It is generally assumed that AP endonucleases play a major role, but the contribution of AP lyases to TMZ-resistance remains largely unknown. Furthermore, unprocessed AP sites may generate single- and double-strand DNA breaks, channelling repair through alternative, BER-independent routes. Since DNA repair mechanisms contribute to TMZ resistance and are epigenetically regulated, tumour-specific DNA repair and epigenetic signatures may be used as predictive biomarkers of patient response to treatment. In this context, in order to move towards personalised therapy in cancer treatment, GLIOCHEM aims to generate new knowledge about the causes of resistance to TMZ in GBM cell lines, allowing the identification of biomarkers than can predict response to treatment and the identification of new therapeutic targets.\t\t\t\t\t\t  <\/div>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<!-- Inner panel End -->\r\n\t\t\t\t\t\r\n\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t<!-- Inner panel Start -->\r\n\t\t\t\t\t<div class=\"wpsm_panel wpsm_panel-default\">\r\n\t\t\t\t\t\t<div class=\"wpsm_panel-heading\" role=\"tab\" >\r\n\t\t\t\t\t\t  <h4 class=\"wpsm_panel-title\">\r\n\t\t\t\t\t\t\t<a  class=\"collapsed\"  data-toggle=\"collapse\" data-parent=\"\" href=\"javascript:void(0)\" data-target=\"#ac_1101_collapse2\"  >\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"ac_open_cl_icon fa fa-plus\"><\/span>\r\n\t\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\t \r\n\t\t\t\t\t\t\t\t<span class=\"ac_title_class\">\r\n\t\t\t\t\t\t\t\t\tObjectives\t\t\t\t\t\t\t\t<\/span>\r\n\t\t\t\t\t\t\t<\/a>\r\n\t\t\t\t\t\t  <\/h4>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t<div id=\"ac_1101_collapse2\" class=\"wpsm_panel-collapse collapse \"  >\r\n\t\t\t\t\t\t  <div class=\"wpsm_panel-body\">\r\n\t\t\t\t\t\t\tGLIOCHEM overall objectives are to study the role of BER-dependent and BER-independent cellular pathways in TMZ-induced methylated lesions and to identify epigenetic biomarkers than can predict response to TMZ. The following specific objectives will be addressed:<\/br>\r\n\r\n<p><strong>Objective 1. <\/strong>Analyse the correlation between resistance to TMZ in GBM cell lines and levels of DNA methylation, expression and activity of DNA repair proteins.<\/br>\r\n<strong>Objective 2. <\/strong>Examine DNA repair capacity and transcriptional response in TMZ sensitive and resistant GBM cell lines.<\/br>\r\n<strong>Objective 3. <\/strong>Study the synthetic lethality of TMZ in combination with topoisomerase I and RNA polymerase I inhibitors.<\/p>\t\t\t\t\t\t  <\/div>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<!-- Inner panel End -->\r\n\t\t\t\t\t\r\n\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\n<h4>Dissemination activities<\/h4>\n<p>&nbsp;<\/p>\n<p><em><strong>European Researchers&#8217; Night 2023<\/strong><\/em><\/p>\n<p><strong>(Epi)genetic maintenance: how our genes are switched on, switched off, and repaired.<\/strong><\/p>\n<p><a href=\"https:\/\/lanochedelosinvestigadores.fundaciondescubre.es\/actividades\/mantenimiento-epigenetico-como-se-encienden-se-apagan-y-se-reparan-nuestros-genes\/\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1709 alignleft\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2023\/10\/maribel-2023.jpg\" alt=\"\" width=\"281\" height=\"191\" srcset=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2023\/10\/maribel-2023.jpg 940w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2023\/10\/maribel-2023-300x204.jpg 300w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2023\/10\/maribel-2023-768x522.jpg 768w\" sizes=\"auto, (max-width: 281px) 100vw, 281px\" \/><\/a><a href=\"https:\/\/lanochedelosinvestigadores.fundaciondescubre.es\/investigador\/ma-isabel-martinez-macias\/\">Maribel<\/a> participated in this workshop at the main event in the University of Cordoba. The researchers explained how DNA labels work and how cells repair damage, and how some diseases like cancer can develop. The team used some hands-on activities and games to show what is DNA, how it functions in different cells, the tools to modify its function and examples of DNA damage.<\/p>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta.png\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1675 alignleft\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2023\/02\/11F-2-e1676470946407.png\" alt=\"\" width=\"346\" height=\"245\" srcset=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2023\/02\/11F-2-e1676470946407.png 1017w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2023\/02\/11F-2-e1676470946407-300x212.png 300w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2023\/02\/11F-2-e1676470946407-768x544.png 768w\" sizes=\"auto, (max-width: 346px) 100vw, 346px\" \/><a href=\"https:\/\/www.un.org\/en\/observances\/women-and-girls-in-science-day\"><strong>International Day of Women and Girls in Science, 11 February<\/strong><\/a><\/p>\n<p>The University of Cordoba organised several activities to <a href=\"http:\/\/www.uco.es\/investigacion\/ucci\/es\/proyecto-cultura-cientifica-11f\">commemorate this day<\/a>, to raise awareness of the scientific accomplishments of women in research and to offer girls role models that promote new vocations as scientists. Maribel went to Lope de Vega secondary school to explain the importance of epigenetics and DNA repair in cancer treatment.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-1680\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2023\/02\/foto-3.jpg\" alt=\"\" width=\"640\" height=\"360\" srcset=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2023\/02\/foto-3.jpg 640w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2023\/02\/foto-3-300x169.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta.png\" \/><\/p>\n<p><em><strong>European Researchers&#8217; Night 2022<\/strong><\/em><\/p>\n<p><a href=\"https:\/\/lanochedelosinvestigadores.fundaciondescubre.es\/actividades\/epigenetica-y-reparacion-del-adn-claves-para-el-tratamiento-contra-el-cancer\/\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1588 alignleft\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/09\/Patios-of-Science-2022-Maribel.png\" alt=\"\" width=\"264\" height=\"274\" srcset=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/09\/Patios-of-Science-2022-Maribel.png 601w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/09\/Patios-of-Science-2022-Maribel-289x300.png 289w\" sizes=\"auto, (max-width: 264px) 100vw, 264px\" \/><\/a><strong>Epigenetics and DNA repair: keys to cancer treatment<\/strong><\/p>\n<p>One of the main problems in the fight against some types of cancer is resistance to chemotherapy-based treatments.<\/p>\n<p>Recent advances highlight the importance of epigenetics and DNA repair in cancer treatment. The aim of this event and discussion between researchers and citizens is to convey the need to generate new knowledge by doing basic research in order to advance in the fight against cancer.<\/p>\n<p>This event has been sold out!<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta.png\" \/><\/p>\n<p><span class=\"css-901oao css-16my406 r-poiln3 r-bcqeeo r-qvutc0\">Maribel Mart\u00ednez and her Supervisor Teresa Rold\u00e1n visited two local high schools to explain their research of epigenetics and DNA repair as part of the activities of the International Day of Women and Girls in Science. The activity was\u00a0organised by the <a href=\"https:\/\/www.uco.es\/ucci\/es\/que-es-la-ucci#:~:text=La%20Unidad%20de%20Cultura%20Cient%C3%ADfica%20e%20Innovaci%C3%B3n%20(UCC%2Bi),tejido%20productivo%20que%20realizan%20otros\" target=\"_blank\" rel=\"noopener\">Unit of Scientific and innovation Culture<\/a> of the University of Cordoba (Unidad de Cultura Cient\u00edfica y de la Innovaci\u00f3n-\u00a0 UCCi).<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1449\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/02\/11F.png\" alt=\"\" width=\"842\" height=\"623\" srcset=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/02\/11F.png 842w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/02\/11F-300x222.png 300w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/02\/11F-768x568.png 768w\" sizes=\"auto, (max-width: 842px) 100vw, 842px\" \/><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta.png\" \/><\/p>\n<p><a href=\"https:\/\/mobile.twitter.com\/ubrseminars\" target=\"_blank\" rel=\"noopener\">UCO BioResearch Seminars (UCO-BRS) \u00a0<\/a>is an Interdisciplinary seminar series where researchers from different departments are invited to give a talk about their work.<\/p>\n<p><span class=\"css-901oao css-16my406 r-poiln3 r-bcqeeo r-qvutc0\">Maribel Mart\u00ednez Mac\u00edas presented her project on Friday 18th of March, under the title: &#8220;DNA damage responses in neurodegeneration and cancer&#8221;<\/span><img loading=\"lazy\" decoding=\"async\" class=\"r-4qtqp9 r-dflpy8 r-sjv1od r-zw8f10 r-10akycc r-h9hxbl\" title=\"DNA\" draggable=\"false\" src=\"https:\/\/abs-0.twimg.com\/emoji\/v2\/svg\/1f9ec.svg\" alt=\"\ud83e\uddec\" width=\"18\" height=\"18\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1475\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/05\/UCO-seminar-Maribel.jpg\" alt=\"\" width=\"680\" height=\"510\" srcset=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/05\/UCO-seminar-Maribel.jpg 680w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/05\/UCO-seminar-Maribel-300x225.jpg 300w\" sizes=\"auto, (max-width: 680px) 100vw, 680px\" \/><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2019\/06\/barra-violeta.png\" \/><\/p>\n<p><span class=\"css-901oao css-16my406 r-poiln3 r-bcqeeo r-qvutc0\">M\u00aa Isabel Mart\u00ednez&#8217;s presented <strong>&#8220;Resistance to temozolomide in glioblastoma: role of DNA repair mechanisms&#8221;<\/strong> at the virtual <a href=\"https:\/\/www.mutagenesisambiental.com\/reuniones\/sema-2022\/\" target=\"_blank\" rel=\"noopener\">XXVI SEMA Scientific Meeting <\/a>on Wednesday 22nd of June 2022.<\/span><\/p>\n<p><a href=\"https:\/\/www.mutagenesisambiental.com\/\">Spanish Environmental Mutagenesis and Genomics Society (SEMA).<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-large wp-image-1558\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/06\/SEMA2022_Maribel_presentation-1024x480.png\" alt=\"\" width=\"700\" height=\"328\" srcset=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/06\/SEMA2022_Maribel_presentation-1024x480.png 1024w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/06\/SEMA2022_Maribel_presentation-300x141.png 300w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/06\/SEMA2022_Maribel_presentation-768x360.png 768w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/06\/SEMA2022_Maribel_presentation.png 1117w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Maribel Mart\u00ednez Mac\u00edas (PhD) is a member of the IMIBIC group GC22 Epigenetics, under the supervision of the group leader Prof. Teresa Rold\u00e1n. Her project is titled GLIOCHEM &#8211; Repair of temozolomide-induced DNA damage in tumour cells: role in glioblastoma&hellip; <\/p>\n","protected":false},"author":2,"featured_media":1709,"parent":931,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-923","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=\/wp\/v2\/pages\/923","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=923"}],"version-history":[{"count":27,"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=\/wp\/v2\/pages\/923\/revisions"}],"predecessor-version":[{"id":1710,"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=\/wp\/v2\/pages\/923\/revisions\/1710"}],"up":[{"embeddable":true,"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=\/wp\/v2\/pages\/931"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=\/wp\/v2\/media\/1709"}],"wp:attachment":[{"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=923"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}