{"id":929,"date":"2021-02-11T17:38:22","date_gmt":"2021-02-11T16:38:22","guid":{"rendered":"https:\/\/p2med.imibic.org\/?page_id=929"},"modified":"2022-05-12T14:46:30","modified_gmt":"2022-05-12T12:46:30","slug":"hidelis","status":"publish","type":"page","link":"https:\/\/p2med.imibic.org\/?page_id=929","title":{"rendered":"HIDELIS"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1010 alignleft\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2021\/02\/Almu_redonda-1.png\" alt=\"Almudena Pino \u00c1ngeles\" width=\"160\" height=\"161\" \/><strong>Almudena Pino \u00c1ngeles<\/strong> (PhD) is a member of the GC09 Nutrigenomics &#8211; Metabolic Syndrome research group, under the supervision of Prof. Pablo P\u00e9rez Mart\u00ednez. Her project is titled <strong>HIDELIS &#8211; Linking structure and dynamics to protein malfunction in Cardiovascular Disease<\/strong>. The results of her project are expected to generate new knowledge at the molecular level of Reverse Cholesterol Transport and ultimately guide the design and development of improved and more specific therapeutic approaches to Cardiovascular Diseases. Almudena&#8217;s project will last from February 2021 till January 2023.<\/p>\n\t\t\t\t\t\t<style>\r\n\t\t\t\t#wpsm_accordion_1088 .wpsm_panel-heading{\r\n\tpadding:0px !important;\r\n}\r\n#wpsm_accordion_1088 .wpsm_panel-title {\r\n\tmargin:0px !important; \r\n\ttext-transform:none !important;\r\n\tline-height: 1 !important;\r\n}\r\n#wpsm_accordion_1088 .wpsm_panel-title a{\r\n\ttext-decoration:none;\r\n\toverflow:hidden;\r\n\tdisplay:block;\r\n\tpadding:0px;\r\n\tfont-size: 16px !important;\r\n\tfont-family: Arial !important;\r\n\tcolor:#000000 !important;\r\n\tborder-bottom:0px !important;\r\n}\r\n\r\n#wpsm_accordion_1088 .wpsm_panel-title a:focus {\r\noutline: 0px !important;\r\n}\r\n\r\n#wpsm_accordion_1088 .wpsm_panel-title a:hover, #wpsm_accordion_1088 .wpsm_panel-title a:focus {\r\n\tcolor:#000000 !important;\r\n}\r\n#wpsm_accordion_1088 .acc-a{\r\n\tcolor: #000000 !important;\r\n\tbackground-color:#5a8992 !important;\r\n\tborder-color: #ddd;\r\n}\r\n#wpsm_accordion_1088 .wpsm_panel-default > .wpsm_panel-heading{\r\n\tcolor: #000000 !important;\r\n\tbackground-color: #5a8992 !important;\r\n\tborder-color: #5a8992 !important;\r\n\tborder-top-left-radius: 0px;\r\n\tborder-top-right-radius: 0px;\r\n}\r\n#wpsm_accordion_1088 .wpsm_panel-default {\r\n\t\tborder:1px solid transparent !important;\r\n\t}\r\n#wpsm_accordion_1088 {\r\n\tmargin-bottom: 20px;\r\n\toverflow: hidden;\r\n\tfloat: none;\r\n\twidth: 100%;\r\n\tdisplay: block;\r\n}\r\n#wpsm_accordion_1088 .ac_title_class{\r\n\tdisplay: block;\r\n\tpadding-top: 12px;\r\n\tpadding-bottom: 12px;\r\n\tpadding-left: 15px;\r\n\tpadding-right: 15px;\r\n}\r\n#wpsm_accordion_1088  .wpsm_panel {\r\n\toverflow:hidden;\r\n\t-webkit-box-shadow: 0 0px 0px rgba(0, 0, 0, .05);\r\n\tbox-shadow: 0 0px 0px rgba(0, 0, 0, .05);\r\n\t\tborder-radius: 4px;\r\n\t}\r\n#wpsm_accordion_1088  .wpsm_panel + .wpsm_panel {\r\n\t\tmargin-top: 5px;\r\n\t}\r\n#wpsm_accordion_1088  .wpsm_panel-body{\r\n\tbackground-color:#f8f8f8 !important;\r\n\tcolor:#000000 !important;\r\n\tborder-top-color: #5a8992 !important;\r\n\tfont-size:14px !important;\r\n\tfont-family: Arial !important;\r\n\toverflow: hidden;\r\n\t\tborder: 2px solid transparent !important;\r\n\t}\r\n\r\n#wpsm_accordion_1088 .ac_open_cl_icon{\r\n\tbackground-color:#5a8992 !important;\r\n\tcolor: #000000 !important;\r\n\tfloat:right !important;\r\n\tpadding-top: 12px !important;\r\n\tpadding-bottom: 12px !important;\r\n\tline-height: 1.0 !important;\r\n\tpadding-left: 15px !important;\r\n\tpadding-right: 15px !important;\r\n\tdisplay: inline-block !important;\r\n}\r\n\r\n\t\t\t\r\n\t\t\t\t\r\n\t\r\n\t\t\t<\/style>\r\n\t\t\t<div class=\"wpsm_panel-group\" id=\"wpsm_accordion_1088\" >\r\n\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t<!-- Inner panel Start -->\r\n\t\t\t\t\t<div class=\"wpsm_panel wpsm_panel-default\">\r\n\t\t\t\t\t\t<div class=\"wpsm_panel-heading\" role=\"tab\" >\r\n\t\t\t\t\t\t  <h4 class=\"wpsm_panel-title\">\r\n\t\t\t\t\t\t\t<a  class=\"\"  data-toggle=\"collapse\" data-parent=\"\" href=\"javascript:void(0)\" data-target=\"#ac_1088_collapse1\"  >\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"ac_open_cl_icon fa fa-plus\"><\/span>\r\n\t\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\t \r\n\t\t\t\t\t\t\t\t<span class=\"ac_title_class\">\r\n\t\t\t\t\t\t\t\t\tAbstract\t\t\t\t\t\t\t\t<\/span>\r\n\t\t\t\t\t\t\t<\/a>\r\n\t\t\t\t\t\t  <\/h4>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t<div id=\"ac_1088_collapse1\" class=\"wpsm_panel-collapse collapse \"  >\r\n\t\t\t\t\t\t  <div class=\"wpsm_panel-body\">\r\n\t\t\t\t\t\t\t<p>Cardiovascular Disease (CVD) is a set of multifactorial pathologies that cause over 30% of the annual deaths worldwide and they are the most frequent cause of death in the European Union. Exploring the vast complexity of the biological mechanisms and patient-dependent factors in CVD represents a challenge that requires joint multidisciplinary efforts to be tackled successfully. The present project aims to obtain novel knowledge at the molecular level of Reverse Cholesterol Transport (RCT), one of the key hallmarks for CVD. Our results will ultimately guide the design and development of improved and more specific therapeutic approaches to CVD. Becoming an IMIBIC-P2Med fellow will have a decisive impact in my career since I will get the full support of the institution to develop critical skills, such as mentoring, leadership and management, through focused training and teaching activities.<\/p>\t\t\t\t\t\t  <\/div>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<!-- Inner panel End -->\r\n\t\t\t\t\t\r\n\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t<!-- Inner panel Start -->\r\n\t\t\t\t\t<div class=\"wpsm_panel wpsm_panel-default\">\r\n\t\t\t\t\t\t<div class=\"wpsm_panel-heading\" role=\"tab\" >\r\n\t\t\t\t\t\t  <h4 class=\"wpsm_panel-title\">\r\n\t\t\t\t\t\t\t<a  class=\"collapsed\"  data-toggle=\"collapse\" data-parent=\"\" href=\"javascript:void(0)\" data-target=\"#ac_1088_collapse2\"  >\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"ac_open_cl_icon fa fa-plus\"><\/span>\r\n\t\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\t \r\n\t\t\t\t\t\t\t\t<span class=\"ac_title_class\">\r\n\t\t\t\t\t\t\t\t\tObjectives\t\t\t\t\t\t\t\t<\/span>\r\n\t\t\t\t\t\t\t<\/a>\r\n\t\t\t\t\t\t  <\/h4>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t<div id=\"ac_1088_collapse2\" class=\"wpsm_panel-collapse collapse \"  >\r\n\t\t\t\t\t\t  <div class=\"wpsm_panel-body\">\r\n\t\t\t\t\t\t\t<p>The objective of the HIDELIS project is to study the structural features and dynamics guiding the paraoxonase 1 (PON1) activity, a key antioxidant marker, and the serum amyloid A (SAA) activity, and anti-inflammatory marker, in the context of the HDL particle. To obtain a comprehensive view of their mechanisms of action in a native-like environment, I will explore the interaction of these proteins with the lipidic bilayer, and its relevance to apolipoproteinA-I, the main scaffold protein in HDL.<\/p>\r\n\r\n<p>With this integrative view, I aim to obtain novel information of the structure-function relationship of these key proteins in HDL that will allow us to rationalize the molecular basis for their activity and their impact in the loss of HDL functionality. This new knowledge will allow us to devise new therapeutic approaches to modulate these essential activities in dysfunctional HDL in the context of CVD and atherosclerosis.<\/p>\r\n\t\t\t\t\t\t  <\/div>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<!-- Inner panel End -->\r\n\t\t\t\t\t\r\n\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\n<h4>Dissemination Activities<\/h4>\n<p><a href=\"https:\/\/mobile.twitter.com\/ubrseminars\" target=\"_blank\" rel=\"noopener\">UCO BioResearch Seminars (UCO-BRS)\u00a0<\/a>is an Interdisciplinary seminar series where researchers from different departments are invited to give a\u00a0 talk about their work.<\/p>\n<p><span class=\"css-901oao css-16my406 r-poiln3 r-bcqeeo r-qvutc0\">Almudena talked about the IMIBIC-P2Med project on the 1st of April 2022. Her talk was titled &#8220;Functional Regulation of Hig density lipoproteins during health and cardiovascular disease&#8221;.<\/span><\/p>\n<p><span class=\"css-901oao css-16my406 r-poiln3 r-bcqeeo r-qvutc0\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1477\" src=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/05\/UCO_seminar_Almudena.jpg\" alt=\"\" width=\"680\" height=\"499\" srcset=\"https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/05\/UCO_seminar_Almudena.jpg 680w, https:\/\/p2med.imibic.org\/wp-content\/uploads\/2022\/05\/UCO_seminar_Almudena-300x220.jpg 300w\" sizes=\"auto, (max-width: 680px) 100vw, 680px\" \/>\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Almudena Pino \u00c1ngeles (PhD) is a member of the GC09 Nutrigenomics &#8211; Metabolic Syndrome research group, under the supervision of Prof. Pablo P\u00e9rez Mart\u00ednez. Her project is titled HIDELIS &#8211; Linking structure and dynamics to protein malfunction in Cardiovascular Disease.&hellip; <\/p>\n","protected":false},"author":2,"featured_media":0,"parent":931,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-929","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=\/wp\/v2\/pages\/929","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=929"}],"version-history":[{"count":20,"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=\/wp\/v2\/pages\/929\/revisions"}],"predecessor-version":[{"id":1478,"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=\/wp\/v2\/pages\/929\/revisions\/1478"}],"up":[{"embeddable":true,"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=\/wp\/v2\/pages\/931"}],"wp:attachment":[{"href":"https:\/\/p2med.imibic.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=929"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}