Maribel Martínez Macías (PhD) is a member of the IMIBIC group GC22 Epigenetics, under the supervision of the group leader Prof. Teresa Roldán. Her project is titled GLIOCHEM – Repair of temozolomide-induced DNA damage in tumour cells: role in glioblastoma resistance to chemotherapy. This project aims to generate new knowledge on the molecular mechanisms involved in resistance to temozolomide, a DNA methylating agent used in the treatment of several types of cancer including glioblastoma (brain tumour). Moving towards personalised cancer therapy, the expected results include the identification of new therapeutic targets and predictive biomarkers for methylating anticancer treatment. Maribel’s project will last from January 2021 till December 2023.
Objective 1. Analyse the correlation between resistance to TMZ in GBM cell lines and levels of DNA methylation, expression and activity of DNA repair proteins. Objective 2. Examine DNA repair capacity and transcriptional response in TMZ sensitive and resistant GBM cell lines. Objective 3. Study the synthetic lethality of TMZ in combination with topoisomerase I and RNA polymerase I inhibitors.
Maribel Martínez and her Supervisor Teresa Roldán visited two local high schools to explain their research of epigenetics and DNA repair as part of the activities of the International Day of Women and Girls in Science. The activity was organised by the Unit of Scientific and innovation Culture of the University of Cordoba (Unidad de Cultura Científica y de la Innovación- UCCi).
UCO BioResearch Seminars (UCO-BRS) is an Interdisciplinary seminar series where researchers from different departments are invited to give a talk about their work.
Maribel Martínez Macías presented her project on Friday 18th of March, under the title: “DNA damage responses in neurodegeneration and cancer”